Derby winner Orb impresses with workout at Belmont

NEW YORK (AP) ? Orb is ready.

The Kentucky Derby winner put in his final workout before the Preakness, breezing four furlongs in 47.18 seconds, galloping out five furlongs in 59.54 and delighting trainer Shug McGaughey.

"I thought it was breathtaking," McGaughey said Monday morning.

With exercise rider Jennifer Patterson aboard, Orb seemed to move effortlessly around the track on a clear, sunny day. In fact, McGaughey called it more impressive than the colt's workout before he won the Derby by 2? lengths on May 4.

"For him to go off nice and relaxed in 24 and change and come home on his own the way he did, and gallop out the way he did, and drop his head and walk home, it sent cold chills up my back," the Hall of Fame trainer said.

After cooling down and receiving a sponge bath, Orb was loaded onto a van headed to Pimlico Race Course in Baltimore. A win in the 1 3/16-mile Preakness on Saturday would set up a Triple Crown try in the Belmont Stakes on June 8. The last Triple Crown winner was Affirmed in 1978.

McGaughey wasn't concerned with the fast fractions, which come nine days after running 1? miles in the Derby.

"I think it's a tribute to the way he came out of the Derby, and to come back and be able to have a work like that and do it the way he did it ? I couldn't be more thrilled," he said. "Right now I'm on cloud nine. The way he was striding today, the way he held his leads through the lane, I thought it was spectacular."

Orb, owned by the Phipps Stable and Stuart Janney III, takes a five-race winning streak in the Preakness, where he will face what look to be nine challengers. Among them are Derby runners Mylute (fifth), Oxbow (sixth), Will Take Charge (eighth), Itsmyluckyday (15th) and Goldencents (17th). Also set for the race is Departing, winner of the Illinois Derby.

"I think it's formidable," McGaughey said. "I know that Oxbow made a good run in the Derby. I never really kind of sat down and watched it and pinned it down. The other horse (Will Take Charge) got in some trouble. You've got to respect Departing coming in there off his race in the Illinois Derby and being relatively fresh. My main concern is just trying to get Orb over there the best way we possibly can and if he runs his race I think they'll know he's in there."

___

Follow Richard Rosenblatt on Twitter at: http://www.twitter.com/rosenblattap

Source: http://news.yahoo.com/derby-winner-orb-impresses-workout-belmont-122439179.html

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Benghazi, IRS, immigration and repealing 'Obamacare' (again): The week to come in Congress (Washington Post)

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Research on cilia heats up: Implications for hearing, vision loss and kidney disease

Research on cilia heats up: Implications for hearing, vision loss and kidney disease

Monday, May 13, 2013

Experiments at Johns Hopkins have unearthed clues about which protein signaling molecules are allowed into hollow, hair-like "antennae," called cilia, that alert cells to critical changes in their environments.

Researchers found that the size limit for entry is much greater than previously thought, allowing most of a cell's proteins into cilia. The researchers believe that the specific collection of proteins in each cilium, customized to the needs of each cell type, is determined by whether and how cilia keep proteins inside once they enter ?? not which ones they allow in initially.

"According to our experiments, 90 percent of the proteins in mammalian cells should be able to fit inside cilia based on their size," says Takanari Inoue, Ph.D., assistant professor of cell biology at the Johns Hopkins University School of Medicine. "But most of them have never been found [inside the cilia], so we think that most proteins do wander in at some point, but only certain ones remain inside."

So-called "primary cilia" have been attracting intense attention as recent research has confirmed their role in monitoring the cell's exterior environment and conveying information to the rest of the cell using an arsenal of signals stored inside the thin interior of each antenna-like cilium. The results of this study, which help explain how that arsenal is developed, will be published online in the journal Nature Chemical Biology on May 12.

Primary cilia are found protruding from most cells in a wide variety of organisms, and defects in cilia have been implicated in everything from polycystic kidney disease to vision and hearing loss. In the kidney, they monitor the flow of urine; in the eye, they sense the wavelength of light; in cartilage, they sense pressure; and in the heart, blood flow. No matter where they are, Inoue says, their job is to translate such mechanical forces?or, in some cases, chemical ones?into molecular signals for the cell, so that it can respond appropriately to its environment.

The signaling molecules inside cilia are tailored to the required responses. For example, some are proteins that bind to DNA to modify gene activity, letting a cell respond to environmental cues by producing more of a particular protein.

The only way into the cilial column is through a hole at its base. "A cilium forms like a short drinking straw being pushed outwards from inside an inflated balloon," says Inoue. "What we don't know is whether there is some sort of cap over the hole, regulating what goes in and out. We found that more signaling molecules can enter the straw than we thought."

"Primary cilia are really difficult to study," Inoue says, "because they are so small and narrow, with each cilium just 1/10,000th the volume of the rest of the cell."

Previous research in other laboratories suggests that a fixed pore exists at the base of a cilium that only allows relatively small molecules inside. By developing more sensitive experimental methods, the Inoue group was able to show that molecules almost 10 times larger than those known before could enter.

Specifically, they first engineered an anchor-like molecule that selectively embedded itself in the membranes of cilia. On the inside end of the anchor was half of a "molecular snapper." Inside the watery interior of the cell, the team placed fluorescent molecules of known size, fitted with the other half of the molecular snapper. If these fluorescent molecules entered cilia, they would carry their fluorescence with them and be trapped inside when the snappers clicked together, allowing the researchers to easily take images of them.

By repeating this experiment many times with molecules of increasing size, the Inoue team was able to show that every molecular size they tested was able to enter the cilia. The only difference between the molecules of different sizes was their rate of entry: Smaller molecules entered more quickly than larger ones.

Figuring out how cilia select their captives is a question for another study, Inoue says.

###

Johns Hopkins Medicine: http://www.hopkinsmedicine.org

Thanks to Johns Hopkins Medicine for this article.

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Source: http://www.labspaces.net/128214/Research_on_cilia_heats_up__Implications_for_hearing__vision_loss_and_kidney_disease

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We're liveblogging Nokia's Lumia event in London, tomorrow at 5am ET!

Nokia's Verizon-bound Lumia 928 may already be a reality, but there's still more to reveal, with the company's London-based Lumia event set to start Tuesday morning. We'll be there from the keen 10AM BST kickoff, so be sure to bookmark our liveblog page to ensure you get all the news. Wondering how that works in your particular time-zone? Consult the magic time bubble below and add your Lumia hopes and dreams in the comments below.

May 14, 2013 5:00 AM EDT

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4 of NHL's Original 6 among 8 still in playoffs

Chicago Blackhawks' Marian Hossa, right, celebrates after scoring his second goal as Minnesota Wild goalie Josh Harding (37) and Jared Spurgeon (46) react during the second period of Game 5 of an NHL hockey Stanley Cup first-round playoff series in Chicago, Thursday, May 9, 2013. (AP Photo/Nam Y. Huh)

Chicago Blackhawks' Marian Hossa, right, celebrates after scoring his second goal as Minnesota Wild goalie Josh Harding (37) and Jared Spurgeon (46) react during the second period of Game 5 of an NHL hockey Stanley Cup first-round playoff series in Chicago, Thursday, May 9, 2013. (AP Photo/Nam Y. Huh)

Detroit Red Wings goalie Jimmy Howard stops a shot during the first period in Game 7 of their first-round NHL hockey Stanley Cup playoff series against the Anaheim Ducks in Anaheim, Calif., Sunday, May 12, 2013. (AP Photo/Chris Carlson)

Boston Bruins right wing Jaromir Jagr skates during a warm up prior to facing the Toronto Maple Leafs in Game 7 of their NHL hockey Stanley Cup playoff series in Boston, Monday, May 13, 2013. (AP Photo/Charles Krupa)

New York Rangers right wing Ryan Callahan (24) celebrates his goal with teammates Carl Hagelin (62) and Derek Stepan (21) against the Washington Capitals during the third period of Game 7 first-round NHL Stanley Cup playoff hockey series, Monday, May 13, 2013, in Washington. The Rangers won 5-0. (AP Photo/Nick Wass)

Los Angeles Kings' Drew Doughty, left, and goalie Jonathan Quick celebrate their team's 2-1 win against the St. Louis Blues in Game 6 of a first-round NHL hockey Stanley Cup playoff series in Los Angeles, Friday, May 10, 2013. (AP Photo/Jae C. Hong)

The NHL playoffs are off to a heart-pounding start with a record 17 games going to overtime in the first round.

The end-to-end, hard-hitting action with storied franchises and superstars might become intriguing enough to attract some casual fans for the conference semifinals.

Original Six teams ? Chicago and Detroit, Boston and the New York Rangers ? are paired up in each conference for the first time since the 1992 postseason.

And, the other two second-round matchups aren't too shabby.

The last five champions ? Los Angeles, Boston, Chicago, Pittsburgh and Detroit ? all have a chance to be the first to win two Stanley Cups in the salary cap era.

The Penguins were scheduled to get their series started Tuesday night at home against Ottawa, and the defending champion Los Angeles Kings were to follow by hosting the San Jose Sharks.

Chicago, the NHL's top-seeded team, will renew a rivalry against seventh-seeded Detroit on Wednesday night in the Windy City. After getting a much-needed break following Game 7s, the fourth-seeded Bruins will host the sixth-seeded Rangers on Thursday night in their first postseason matchup since 1973.

The last time Original Six teams faced each other on both sides of the NHL postseason bracket beyond the first round was the division finals in 1992 when Montreal and Boston played in the Wales Conference while the Blackhawks and Red Wings met in the Campbell Conference, according to STATS.

Since then, the NHL has had three work stoppages, including one this season that started the season on Jan. 19 and shortened it to a 48-game sprint.

The timing off the Original Six-heavy playoffs, leading to four major markets likely spiking TV ratings, seems to be the shot the sport needs.

"I think it's great for the league," Red Wings forward Justin Abdelkader said. "Any time you have Original Six team matchups or Original Six teams in the playoffs, it's great.

"We're looking forward to playing Chicago one last time before we change conferences."

The Red Wings will be in the Eastern Conference next season as part of the league's realignment plan, making their 13th best-of-seven series against the Blackhawks even more interesting.

Detroit, though, will have to fare better than it did against Chicago in the regular season to make the matchup compelling after the pre-series hype fades.

The Blackhawks, the NHL's top-seeded team, beat the Red Wings twice in shootouts, once in overtime and by a 7-1 score in another game.

"Maybe we had their number during the regular season, but this is different," said Chicago forward Marian Hossa, who played for Detroit the last time the teams met in the playoffs four years ago when the Red Wings rolled toward the Stanley Cup finals. "When I saw how they played (against Anaheim), they've extremely picked up their game and played well.

"We will have to be better than we were against Minnesota if we want to win."

Boston couldn't have finished better in the first round, becoming the first team to win a Game 7 after trailing by three goals in the third.

The Bruins were down by two with 90 seconds left, scored twice in a 31-second span and beat Toronto ? another Original Six team ? in the league's 17th OT game of the postseason. The previous record for OT games in an opening round was 16, set last year.

The Rangers had a much easier time in their decisive game against Washington, winning 5-0 with Henrik Lundqvist becoming the first NHL goaltender to have shutouts in Games 6 and 7 since Detroit's Dominik Hasek did it in 2002.

It was such a rout that New York forward Arron Asham was peeking at the Toronto-Boston score to see who the Rangers would play next.

"I looked up a few times and saw that Toronto was up 4-1, and that's who I thought we'd face," Asham said. "A few minutes later, it was a different story. It's a tough way to lose.

New York took the three-game season series against the Bruins, winning a shootout and an OT game after opening the season with a 3-1 loss to them. But Boston coach Claude Julien is counting on his team building confidence from its comeback that might help its quest for consistency.

"That's the one thing that I'm hoping, that we can grab that momentum that we had at the end and carry it into the next series," Julien said. "We know we have to be better, we can't keep playing well in spurts and not so well in other spurts."

On the other side of North America, two teams will compete to be California's best hockey club.

The fifth-seeded Kings and sixth-seeded Sharks are playing for the second time in the playoffs ? San Jose eliminated Los Angeles in the opening round three years ago ? and are the first teams from the Golden State to meet after the opening round of the playoffs.

"It's a great thing for the state," Sharks coach Todd McLellan said.

Canada had one-fourth of the 16 teams in the playoffs when they began April 30. Now, the hockey-crazed country is left with only the seventh-seeded Senators going against one of the country's own, Sidney Crosby, and the Penguins, the top-seeded team in the East.

Crosby has bounced back from a broken jaw well enough to have a point in each of his five games against the Islanders in the first round, scoring three goals and making six assists to quiet questions about his health.

The superstar was eliminated by Ottawa in his first postseason in 2007 and helped Pittsburgh knock the Senators out of the first round the next year and 2010.

Adding a layer of drama to the series, Senators owner Eugene Melnyk has called Penguins winger Matt Cooke "a goon" after his skate slashed the Achilles tendon of Ottawa defenseman Erik Karlsson on Feb. 13.

"I don't think you need much motivation in the playoffs, but I think both teams should be pretty motivated," Crosby acknowledged.

___

AP Sports Writers Jay Cohen in Chicago, Howard Fendrich in Washington, Josh Dubow in San Jose, Calif., and Will Graves in Pittsburgh contributed to this report.

___

Follow Larry Lage on Twitter at www.Twitter.com/larrylage

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-05-14-HKN-NHL-Original-Six/id-500c121d3e7e4665a5e15793735bf6c5

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2 injured in W.Va. gas plant explosion

POCA, W.Va. (AP) -- Two workers were injured Monday when highly flammable gas used in welding exploded at a West Virginia industrial site, officials said.

Fire crews were sent at about 3:20 p.m. to Airgas, a distributor of specialty gases in Poca, outside of Charleston. Putnam County emergency management director Frank Chapman said the explosion involved about 50 tanks of acetylene that were at Airgas waiting to be refilled. What caused the tanks to explode wasn't known.

Chad Jones, a firefighter with the Bancroft Volunteer Fire Department, said four cylinders continued to burn Monday evening and that crews were letting them "burn out." They were dousing other tanks with water to keep them from exploding, said Jones, whose station was one of several to respond to the scene.

The tanks were being stored in a bay behind the facility. Jones said after the first tank exploded, "it was like a chain reaction," with fireballs shooting 100 to 150 feet in the air. A nearby business was evacuated, and windows were shattered in the back of the Airgas plant, Jones said.

Doug Barker, chief financial officer at nearby Clark Truck Parts, told The Associated Press over the phone that "we felt our building shake like it's never come close to shaking before from a storm or anything. It was enough to make us run."

Barker said he and another company official bolted from their offices, and he ran to the road and saw dark smoke in the air. Soon afterward, they heard several smaller explosions and saw fire, he said. Barker also saw three or four ambulances speed by and heard a lot of sirens.

Clark Truck Parts is about half-mile from Airgas, Barker said. He said there are some homes between the two industrial sites.

Dave Castro, manager of the TransWood trucking company about a quarter-mile from Airgas, said he also felt his building shake.

"It felt like a truck ran into the building," he said.

He said he drove toward Airgas to check on his wife, who works at another company nearby, and could see the back of the plant on fire. He said the burning area was about the size of a house, and every 15 seconds or so a black ball of smoke would rise from a tank or drum "and explode like a firework."

Acetylene is used in welding canisters. Airgas calls itself the largest U.S. supplier of industrial, medical and special gases. The company also lists on its website propane, often used in backyard grills; hydrogen, helium; and nitrous oxide, or the "laughing gas" used during some dental procedures.

Company spokesman Doug Sherman said the explosions occurred in a concrete-enclosed storage area located outside of the main plant. He said the injuries were not life-threatening, and the fire had been extinguished.

Jones said the company was sending a hazmat crew from Kentucky.

"It's a hazardous job they do every day," Jones said. "Something went wrong today."

A U.S. Occupational Safety and Health Administration crew was at the scene.

Chapman said the explosion involved residue of the gas left in the tanks. He said the blast would have been much worse if the tanks were filled. He said both workers suffered second and third-degree burns.

Chapman said the cause of the explosion was being investigated and that the blasts and fire were the first problem he knows to be reported at Airgas.

The injured workers were taken to Cabell Huntington Hospital for treatment. A hospital official did not know their conditions.

Airgas Inc. is based in Radnor, Pa., and has more than 15,000 employees at 1,110 locations including retail stores, gas fill plants and distribution centers, according to Hoover's database on companies. It is the largest distributor of packaged gases in the US, with a 25 percent market share and with sales of nearly $5 billion in fiscal 2012.

Source: http://news.yahoo.com/2-hurt-explosions-fire-w-001243069.html

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The Wackiest Moms of the Animal Kingdom

Mom, mother, madre, mutter, mama, mum ? whatever you call her, everyone has one. While Mother's Day celebrates human mothers, there are a lot of other moms in the animal kingdom worth a shout-out.

They run the gamut from supremely selfless to downright devious. Here's a look at some of the wackiest animal mothers.

1. Kangaroo adopters

The roo riding around in a kangaroo's pouch may not be her own. That's right: Female kangaroos sometimes adopt baby kangaroos, though it might be accidental. Such an accidental adoption doesn't happen often, but when it does, a mother kangaroo will care for a changeling roo for the rest of its "pouch life" and nurse it for several months afterward during the "young-at-foot" stage, when the juvenile kangaroo permanently exits the pouch. [Marsupial Gallery: A Pouchful of Cute]

While there have been a few cases of marsupials fostering babies in captivity, such cases are less common in the wild. Still, some animals, such as sea lions, have been known to adopt in the wild.

2. Cuckoo sneak

When it comes to rearing young, female cuckoo birds farm the task out to others. Cuckoo moms lay their eggs in the nests of other birds, which raise them unwittingly. Often, the other birds are a smaller species, and the cuckoo chick hatches first, grows faster and kicks the other chicks out of the nest. The other chicks die, and the cheeky cuckoo receives all of the adoptive mother's attention.

3. Blood-sucking ants

Count Dracula isn't the only creature with a taste for bodily fluids: The tiny, endangered Adetomyrma ant from Madagascar drinks the fluids of its own young. After the queen ant gives birth to her larvae, she and the other worker ants gnaw holes in the larvae and suck out the circulatory system fluid known as haemolymph (the insect equivalent of blood). Luckily, the baby ants survive this so-called nondestructive cannibalism, but it can't be very pleasant. It's not clear why the behavior exists, but transferring fluids may be a form of social behavior in the ants, scientists say.

4. Monkey baby killers

Some animals head off motherhood before it starts, to spare their babies undue hardship after they're born. When a male gelada baboon takes over a breeding group from a previous male, he usually kills any babies of the former union. To prevent the bloodshed, pregnant female geladas will often spontaneously have a miscarriage. The phenomenon was first discovered in 1959 in mice, by biologist Hilda Bruce, and is known as the Bruce effect. It has since been reported in other rodent species, but was not known to exist outside the lab until scientists observed it in geladas.

5. Spider cannibals

The female Stegodyphus spider is the ultimate selfless mother. She watches over her egg cocoon until her babies hatch, at which point she starts regurgitating most of her meals to feed her offspring. Once the babies are about a month old, mommy spider rolls onto her back, letting her babies climb aboard. There, they inject venom and digestive enzymes into their mother to kill her, and subsequently feast on the remains. Before leaving the nest, some of the ravenous babies cannibalize each other.

7. Bonobo "wing-moms"

Unlike human males, bonobo males hang out with mom when they're trying to find a mate. For low- to mid-ranking bonobos ? one of humans' closest relatives in the primate world ? have more opportunities to mate when their mothers are nearby. Mother bonobos expose their sons to females in her social circle, and scare off rival males. The moms aren't just being helicopter parents ? they stand to pass on their genes if their efforts result in grandkids, researchers say.

8. Frog taxi service

The strawberry poison arrow frog pulls out all the stops when it comes to caring for her little ones. She will lay up to five eggs, and once the tadpoles hatch, she ferries each one on her back from the rain forest floor up to trees as tall as 100 feet (30 meters). Up in the trees, mama frog seeks out safe, water pool nurseries in the leaves for each baby. Mama frog then feeds her hatchlings some of her own unfertilized eggs over the next six to eight weeks of their development into frogs.

Follow Tanya Lewis on Twitterand Google+.?Follow us @livescience, Facebook & Google+. Original article on?LiveScience.com.

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Source: http://news.yahoo.com/wackiest-moms-animal-kingdom-160505156.html

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